Pat chicken breasts dry and season both sides with Italian seasoning, garlic powder, onion powder, paprika, salt, and pepper.
Boil penne pasta in salted water until al dente. Reserve half a cup of pasta water, then drain.
Heat olive oil in a skillet over medium-high heat. Sear chicken for 4 to 5 minutes per side until golden brown, then slice.
Melt butter in the skillet, saute minced garlic for 60 seconds, then simmer heavy cream for 3 minutes.
Whisk in freshly grated Parmesan over low heat until smooth.
Fold in cooked pasta, top with sliced chicken, and garnish with fresh parsley.